| Sanction Date: | 11.01.2024 | |||
| Project Category | SG | |||
| Year | 2023-2024 | |||
| Project Duration | 3 Years | |||
| BTA : | Handling of Waste (HW) | |||
| Project Site/ State/ Districts/ Villages Covered: |
Faculty of Veterinary Sciences & Animal Husbandry, SKUAST-Kashmir |
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| Organization/ Implementation Agency: | Directorate of Sericulture Development Department, Govt of J&K | |||
| Project Partners: | S.No. | Name | ||
| 1. | ||||
| Lead Proponent: | Dr. Syed Mudasir Ahmad Andrabir |
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| Project Brief Description: | Sericulture is an agro-based industry with a great capability of generating substantial employment particularly in rural areas through raw silk production. The resultant by-products of silk production whose economic values are less than the total cost involved in their reprocessing for beneficial use are often termed as ‘sericulture waste’ or ‘seri-waste’. The major wastes and by-products are plant waste (leaves, fruits, stems and barks), silkworm waste, pupal waste, protein waste (sericin and fibroin), post-silk extraction process, etc. The effective utilizations of these products are very much essential for placing sericulture as a promising occupation in farmers’ mind. Therefore, the present sericulture not only focuses on income generation through cocoon selling but also through multiple reutilizations of by-products that can additionally benefit a farm’s economy. The utilization of sericin waste sericin offers a sustainable and eco-friendly approach to repurpose waste materials generated by the silk production industry. It aligns with the principles of circular economy and environmental sustainability by reducing waste and promoting the use of natural, biodegradable materials in various applications. Sericin, a protein biopolymer derived from silkworms, exhibits excellent biocompatibility and biodegradability, making it suitable for use in the human body. Electrospinning allows the fabrication of sericin scaffolds with nanofibrous structures, which closely resemble the natural extracellular matrix (ECM). This mimics the native tissue environment and promotes cell adhesion, proliferation, and differentiation. The high surface area and tenable porosity of sericin electros pun scaffolds enhance nutrient and oxygen diffusion, waste removal, and cell-cell communication, facilitating tissue regeneration. Sericin electro spun scaffolds can also be loaded with bioactive molecules, growth factors, or drugs to provide controlled release, further enhancing their therapeutic potential. These scaffolds have shown promise in various tissue engineering applications, including bone, cartilage, skin, nerve, and vascular tissue regeneration. Mesenchymal stem cells (MSCs), which are a group of cells that can be isolated from various tissues, have been observed to have important therapeutic potential due to their self-renewal capacity and multilineage differentiation potency. MSCs have been shown to improve cutaneous wound healing and skin regeneration by accelerating wound closure, boosting re-epithelialization, increasing angiogenesis, encouraging granulation tissue development, moderating inflammation, and regulating ECM remodeling. | |||
| Beneficiaries/ Stakeholders: |
• Trained human resource on scientific and safe methods for utilizing sericin waste. |
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| Activity Chart | Click Here | |||
| Total Grants (in Rs.) | Rs. 50,00,000 (Rupees: fifty lakh only) | |||
| 1st Installment (in Rs.) : | Rs. 23,05,480 (Rupees: Twenty three lakh five thousand four hundred eighty only) | |||
| Project Objectives | Quantifiable Deliverables | Monitoring Indicators |
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• Extraction and characterization of sericin from silk wastes using standard procedures. • Synthesis and development of polymeric scaffolds from sericin loaded with stem cell exosomes and Phyto molecules having antibacterial and anti-inflammatory properties. • In vitro and in vivo evaluation of the biomaterial for wound healing and tissue regeneration |
• A promising cell-free therapeutic strategy, enhancing the process of healing and reducing wound scars by remodeling of extracellular matrix (ECM). • An effective platform for treatment of chronic wounds in animals and humans. • A base for tissue regeneration studies. • Training of efficient human resources in the area of stem cell research. |
• Successful trial results for well-tested and proven Therapeutic Strategy (No) • No of tissue regeneration studies supported • Trained resources (No.) • Knowledge Products (No.) |
| S.No. | Name (Sanctioned) | Grant under Professoional Services |
| 1. | 01 JRF | @ Rs.31,000/- + HRA |
| 2. | 01 SPF | @ Rs.23,000/- + HRA |
| S.No. | Name of Equipment (Sanctioned) | Cost (in INR) |
| 1. | 01 Nos.- Lyophilizer | 8,00,000/- |
